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20 Figure 4

L-Carnitine supplementation in recovery after exercise

Lancet Diabetes Endocrinol 2016;4:498-506

A crucial role of lactate accumulation in cancer cells has been demonstrated regarding its ability to induce expression of anti-inflammatory and proangiogenic genes, together with the modification of histones through a process called lactylation, where a lactyl-CoA is added to lysine residues present in the tails of histones [33]